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TranscriptomicsCopy number aberrations of genes regulating normal thymus development in thymic epithelial tumors
Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We eval...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-23540 | biostudies-arrayexpress
TranscriptomicsA specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors
Next generation sequencing of 28 thymic epithelial tumors (TETs) revealed a high frequency of GTF2I missense mutation (chr7:74146970T/A) in A thymomas, a relatively indolent subtype. The GTF2I mutation was confirmed in 82% of A and 74% of AB thymomas in a series of 274 TETs but was rare in aggressi...
ORGANISM(S): Homo sapiens 
2014-06-24 | E-GEOD-57892 | biostudies-arrayexpress
TranscriptomicsGTF2I Mutations are Common in Thymic Epithelial Tumors
Within a project aim to define the genomic aberration of thymic epithelial tumors, we performed array CGH in 65 thymic epithelial tumors. Tumor samples were collected during surgery or by image-guided biopsies and immediately frozen. Section from frozen material were cut and stained with Haematoxyli...
ORGANISM(S): Homo sapiens 
2014-06-21 | E-GEOD-55852 | biostudies-arrayexpress
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