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UnknownDiscovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.
Not available
S-EPMC9578044 | biostudies-literature
UnknownA non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
Not available
S-EPMC6065170 | biostudies-literature
UnknownComparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.
Not available
S-EPMC6980506 | biostudies-literature
UnknownA novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.
Not available
S-EPMC5963526 | biostudies-literature
UnknownIdentification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.
Not available
S-EPMC9578043 | biostudies-literature
UnknownRetina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Muller glial cells.
Not available
S-EPMC24788 | biostudies-literature
UnknownThe novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration.
Not available
S-EPMC9560169 | biostudies-literature
UnknownR-Loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin.
Not available
S-EPMC8974437 | biostudies-literature
UnknownDesign, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Not available
S-EPMC6737539 | biostudies-literature
UnknownNovel Therapeutic Strategies Exploiting the Unique Properties of Neuroendocrine Neoplasms.
Not available
S-EPMC10605125 | biostudies-literature
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