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ProteomicsPfDOZI protein-protein interaction in plasmodium falciparum
Here, we characterized an RNA binding protein (RBP), PfDOZI, which is an integral cytoplasmic component of RNP granule. We observed that deleting pfdozi led to an asexual growth advantage due to the escalated merozoite invasion capacity. Also, pfdozi disruption resulted in a significant impairment i...
ORGANISM(S): Plasmodium falciparum 
2024-04-16 | PXD020862 | Pride
Pfdozi Asexual stage Sexual stage Plasmodium falciparum Lc-ms/ms 
ProteomicsThe DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
In malaria parasites, the regulation of mRNA translation, storage and degradation during development and life stage transitions remains largely unknown. Here, we functionally characterized the DEAD-box RNA helicase PfDOZI in P. falciparum. Disruption of pfdozi enhanced asexual proliferation but redu...
ORGANISM(S): Plasmodium falciparum MLW.2749 
2024-04-30 | PXD051782 | Pride
Plasmodium falciparum Post-transcriptional regulation Stress granule. Pfdozi Processing body Rna helicase 
GenomicsThe DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
PRJNA781234 | ENA
TranscriptomicsThe DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
Purpose: In malaria parasites, the regulation of mRNA translation, storage and degradation is a critical aspect of gene expression, especially during the life stage transition. Since the DEAD-box helicases are involved in RNA metabolism, we wanted to determine whether pfdozi disruption led to altere...
ORGANISM(S): Plasmodium falciparum 
2024-04-05 | GSE189034 | GEO
UnknownA bioinformatic survey of RNA-binding proteins in Plasmodium.
Not available
S-EPMC4630921 | biostudies-literature
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