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MetabolomicsGlucagon-induced PGC-1aplha4/PPARgamma promotes hepatic lipid storage and macrosteatosis in fasting and MASLD

Please update the study abstract/descriptionThe liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions in this balance contribute to metabolic disorders, in...

2026-06-16 | MTBLS13087 | MetaboLights
MetabolomicsPGC1-A effect on TCA enzymes
Not available
ORGANISM(S): Mus musculus 
ST001044 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of striata from PGC-1a knockout mice and litter mate controls to understand the roles of PGC-1a.
Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy metabolism have been implicated in HD pathogenesis. We report here that mutant huntingtin causes disruption of mitochondr...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5786 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse C2C12 muscle cells overexpressing PGC-1alpha, PGC-1beta or GFP to investigate differential expression of TNFalpha-induced genes
Differentiated C2C12 cells adenovirally overexpressing either PGC-1alpha or PGC-1beta or GFP as control were treated with TNFalpha for 2h or left untreated. NF-kappaB- and stress-depedent gene expression was determined by a customized array.
ORGANISM(S): Mus musculus 
2012-12-14 | E-MEXP-3676 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse TSC2-/- embryonic fibroblasts: vehicle-treated, rapamycin-treated, gfp-infected, and pgc-1alpha-infected samples reveals the mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex
Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxid...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5332 | biostudies-arrayexpress
MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
TranscriptomicsTranscription profiling of differentiated brown adipocytes from wild type, PGC-1 alpha knockout, or PGC-1 alpha knockout and PGC-1 beta knockdown mice to investigate the roles of PGC-1 coactivators in brown fat differentiation.
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lac...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5042 | biostudies-arrayexpress
TranscriptomicsAnalysis of PGC-1alpha overexpression effects on the whole transcriptome in cultured skeletal muscle cells
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a chief activator of the mitochondrial and metatolic program in skeletal muscle (skm) and prevents atrophy. Here we tested whether PGC-1α overexpression could restructure the transcript...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-28206 | biostudies-arrayexpress
TranscriptomicsMicroarray skeletal muscle PGC-1alpha-/- - beta f/f/Mlc1fCre mice
Title: Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity Abstract: Evidence is emerging that the PGC-1 coactivators serve a critical role in skeletal muscle metabolism, function, and disease. Mice with total PGC-1 defic...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-23365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and PGC-1 alpha knockout mouse mature brown adipocytes treated with or without dibutyryl cAMP to investigate the specific role of PGC-1 coactivators in brown fat cells
To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat diffe...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5041 | biostudies-arrayexpress
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