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TranscriptomicsChromatin immunoprecipitation of wild type, SET2 deletion, Rco1 PHD domain deletion and Eaf3 chromodomain deletion yeast using anti-acetyl-histone H4
Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic initiation of transcription within the coding region. RNA polymerase II signals for deacetylation through methylation of histone H3 lysine 36 (H3K36) which provides the recruitment signal for the Rpd3S deacetylas...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-16 | E-TABM-260 | biostudies-arrayexpress
ProteomicsLack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Hypoxia Inducible Factor (HIF) prolyl hydroxylase domain (PHD) enzymes catalyse the posttranslational hydroxylation of conserved prolyl residues in the alpha-subunit of the HIF transcription factor. These modifications, which promote the degradation of HIF-alpha subunits by the pVHL E3 ligase comple...
ORGANISM(S): Homo sapiens (Human) 
2019-08-30 | PXD013112 | Pride
Human Lc-msms In vitro Phd enzyme Prolyl hydroxylation 
TranscriptomicsJade1 ChIP-chip on ENCODE Tiling array
Several MYST-family histone acetyltransferase (HAT) enzymes associate with specific ING tumor suppressor proteins. ING complexes containing the HBO1 HAT protein are the major source of histone H4 acetylation in vivo and have been shown to play critical roles in gene regulation and DNA replication. H...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14309 | biostudies-arrayexpress
TranscriptomicsGene profiling in murine Map3k1 mutant embryonic stem cells
Transcriptional profiling of gene expression of embryonic stem cells from mutant Map3k1 mice in comparison to control EL14 cells. The differential expression of specific genes between the mutant and control groups generated from the microarray will give an idea of the molecular mechanisms regulating...
ORGANISM(S): Mus musculus 
2014-06-01 | E-MTAB-1679 | biostudies-arrayexpress
UnknownThe MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
Not available
S-EPMC4282369 | biostudies-literature
TranscriptomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: expression analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21555 | biostudies-arrayexpress
GenomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: ChIP-Seq analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21108 | biostudies-arrayexpress
UnknownMultivalent recognition of histone tails by the PHD fingers of CHD5.
Not available
S-EPMC3518043 | biostudies-literature
UnknownStructural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.
Not available
S-EPMC3331790 | biostudies-literature
TranscriptomicsStructures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue
Bypass of Ess1 (Bye1) is a nuclear protein with a domain resembling the central domain in the transcription elongation factor TFIIS. Bye1 binds with its TFIIS-like domain (TLD) to RNA polymerase (Pol) II. Using a Bye1-TAP strain ChIP-chip was performed to examine the genome-wide association of Bye1 ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-23 | E-MTAB-1894 | biostudies-arrayexpress
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