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MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
ProteomicsEngineering cell-free systems by chemoproteomic-assisted phenotypic screening.
Phenotypic screening is a valuable tool to both understand and engineer complex biological systems. We demonstrate the functionality of this approach in the development of cell-free protein synthesis (CFPS) technology. Phenotypic screening identified numerous compounds that enhanced protein produc...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-07-22 | PXD047986 | JPOST Repository
MetabolomicsRapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
MetabolomicsAssessment of phenotypic trait plasticity in the oilseed Camelina sativa using integrated early-stage abiotic stress and field studies

Connecting the characterisation of juvenile (pre-anthesis) plant stress responses undertaken in controlled environments to field agronomic performance is a challenge. The oilseed crop Camelina sativa (camelina), with its innate resilience and plasticity, presents an opportunity to understand both...

2026-02-09 | MTBLS9839 | MetaboLights
GenomicssgRNA library generation and phenotypic screening
NGS for library QC and analysis of phenotypic screening
PRJEB73744 | ENA
ModelsTuron2023 - H3D virtual screening models
The H3D virtual screening cascade contains models for Mycobacterium tuberculosis and Plasmodium falciparum IC50 predictions, as well as ADME, cytotoxicity, and solubility assays. Model Type: Predictive machine learning model. Model Relevance: This panel of models provides predictions for the H3D vi...
2024-05-13 | MODEL2403270001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
UnknownA phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity.
Not available
S-EPMC7046468 | biostudies-literature
GenomicsScalable, compressed phenotypic screening using pooled perturbations (PDAC screens)
Scalable, compressed phenotypic screening using pooled perturbations (PDAC screens)
PRJNA1110737 | ENA
ProteomicsIntegrated Phenotypic and Activity-Based Profiling of Electrophilic Fragments Reveals New Targets for Antibiotics Development
The emergence of antibiotic resistance necessitates the discovery of novel bacterial targets and antimicrobial agents. Here, we present a bacterial target discovery framework that integrates phenotypic screening of cysteine-reactive fragments with competitive activity-based protein profiling to map ...
ORGANISM(S): Shigella flexneri S5644 Bacteria 
2025-05-07 | PXD058002 | Pride
Phenotypic screening  covalent inhibitor  antibiotics  activity-based protein profiling  fabh  miaa  pdxy 
UnknownCompounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.
Not available
S-EPMC8888995 | biostudies-literature
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