Clozapine is an atypical antipsychotic drug used to treat treatment-resistant schizophrenia. Its side effects, including liver enzyme abnormalities, experienced by many patients preclude its more common use as a first-line therapy for schizophrenia. Toxicoproteomic approaches have been demonstrated ...
To associate gene expression profiles with specific features of the splenic CD4+ T-cell repertoire generated during a blood stage P. chabaudi infection, we obtained both transcriptomic and T-cell receptor data from 2 infected mice at 7 days following infection.
The formation of granulomas is associated with the resolution of Q fever, a zoonosis due to Coxiella burnetii; however the molecular mechanisms of granuloma formation remain poorly understood. We generated human granulomas with peripheral blood mononuclear cells and beads coated with C. burnetii, us...
Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined that mutations in CARD14, encoding an NF-kB activator within skin epidermis, account for PSORS2. Here we describe fifteen additional rare, missense variants in CARD14, their distribution in seven psoriasis c...
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
This a model from the article:
Optimal velocity and safety of discontinuous conduction through the
heterogeneous Purkinje-ventricular junction.
Aslanidi OV, Stewart P, Boyett MR, Zhang H. Biophys J
2009 Jul 8;97(1):20-39 19580741
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