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ProteomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation. From exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091157 | MassIVE
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsChronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study: Serum Lipidomics
The overall clinical study used a parallel-group, case-controlled study design in order to identify a biomarker or panel of biomarkers for the differentiation of subjects with mild to moderate COPD (GOLD stage I and II), asymptomatic current smokers, former smokers and never-smokers and to compare p...
2017-02-20 | MTBLS358 | MetaboLights
TranscriptomicsMucosal transcriptomics implicates under expression of FAM5C in the pathogenesis of ulcerative colitis
Background and aims: Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls (HC), taken from macroscopically non-inflamed tissue fr...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-48634 | biostudies-arrayexpress
TranscriptomicsNovel Observations from Next Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
Understanding distinct gene expression patterns of normal adult and developing fetal human pancreatic a and b cells is crucial for developing stem cell therapies, islet regeneration strategies, and therapies designed to increase b cell function in patients with diabetes (type 1 or 2). Toward that en...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-67543 | biostudies-arrayexpress
UnknownCross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020.
Not available
S-EPMC7896375 | biostudies-literature
UnknownSurgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.
Not available
S-EPMC12414919 | biostudies-literature
UnknownCharacteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Not available
S-EPMC8479648 | biostudies-literature
UnknownThe third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.
Not available
S-EPMC10401723 | biostudies-literature
UnknownPerformance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia.
Not available
S-EPMC9877422 | biostudies-literature
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