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ProteomicsRegion and cell-type resolved quantitative proteomic map of the human heart and its application to atrial fibrillation
The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here we determine the healthy human heart proteome by measuring 16 anatomical regions and three major car...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-03 | MSV000084410 | MassIVE
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
ProteomicsMyocardial proteome profiling reveals disease- and sex-specific alterations in patients with aortic valve stenosis and mitral valve regurgitation
Heart valve diseases, such as aortic valve stenosis (AS) and mitral valve regurgitation (MR), are leading causes of heart failure. However, myocardial proteome studies in AS and MR are extremely rare. We profiled the proteome of 75 human left ventricular myocardial biopsies (AS=41, MR=17, controls=1...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD023800 | Pride
Mitral regurgitation Sex differences Cytoskeleton Aortic stenosis Fibrosis Energy metabolism Proteostasis Heart Extracellular matrix 
ProteomicsBoxCar acquisition method enables single shot proteomics at a depth of 10,000 proteins in 100 minutes
Great advances have been made in sensitivity and acquisition speed on the Orbitrap mass analyzer, enabling increasingly deep proteome coverage. However, these advances have been mainly limited to the MS2 level whereas ion beam sampling for the full MS scan remains extremely inefficient. Here we repo...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-10-04 | MSV000084418 | MassIVE
ProteomicsUltra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
The oral cavity is home to one of the most diverse microbial community of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions including lubrication of food, predigesting and bacterial defense. Consequently, disruptions in saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080862 | MassIVE
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Dictyostelium Discoideum (ncbitaxon:44689) Triticum Aestivum (ncbitaxon:4565) Escherichia Coli (ncbitaxon:562) Sus Scrofa Domesticus (ncbitaxon:9825) Gallus Gallus (ncbitaxon:9031) Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) Danio Rerio (ncbitaxon:7955) Saccharomyces Cerevisiae (ncbitaxon:4932) Bos Taurus (ncbitaxon:9913) Drosophila Melanogaster (ncbitaxon:7227) Arabidopsis Thaliana (ncbitaxon:3702) Vitis Vinifera (ncbitaxon:29760) Mus Musculus (ncbitaxon:10090) Caenorhabditis Elegans (ncbitaxon:6239) 
2020-07-10 | MSV000085716 | MassIVE
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-13 | MSV000085728 | MassIVE
ProteomicsProteome Profiling in Cerebrospinal Fluid Reveals Novel Biomarkers of Alzheimer’s Disease
Neurodegenerative diseases are a growing burden and there is an urgent need for better biomarkers for diagnosis, prognosis and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). Alzheimer’s disease (AD) patients ha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-06 | MSV000088649 | MassIVE
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