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TranscriptomicsTranscription profiling of mouse fibroblast cells transfected with zinc-inducible C/EBP expression vectors identifies Per2 as a gene implicated in myeloid leukemia
The zinc-inducible C/EBP expression vectors pMTa, pMTb, pMTd and pMTe were constructed by cloning the human C/EBPa, C/EBPb, C/EBPd and C/EBPe cDNAs, respectively, into the pMTCB6+ vector. NIH 3T3 cells were transfected with zinc-inducible C/EBP vectors as well as control empty vector using the GeneP...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2188 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
Proteomicsprostate cancer LNCaP cell DTP and withdrawal_memory proteins can be biomarkers
we examined the label-free proteomics in untreated LNCaP (NC), DTP-ENZ, R5-ENZ, R10-ENZ, R20-ENZ, DTP-EPI, R5-EPI, R10-EPI, and R20-EPI groups by nanoscale liquid chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS). The groups each with three biological replicates were used for proteom...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD032983 | Pride
Human cell line Label-free Biomarker 
UnknownElevated serum levels of GPX4, NDUFS4, PRDX5, and TXNRD2 as predictive biomarkers for castration resistance in prostate cancer patients: an exploratory study.
Not available
S-EPMC11920399 | biostudies-literature
UnknownPoly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA damaging
Not available
S-SCDT-EMBOR-2018-46166V1 | biostudies-other
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
TranscriptomicsZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma [CaSki]
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusivel...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-86013 | biostudies-arrayexpress
TranscriptomicsZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma [UMSCC1]
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusivel...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-86014 | biostudies-arrayexpress
TranscriptomicsBCL6 enforces human glioblastoma growth and serves as a novel therapeutic target (expression)
ZBTB transcription factors extensively orchestrate gene transcription during tissue development. However, their roles in glioblastoma multiforme (GBM) remain largely unexplored. Here, through integrated functional screening and expression analyses of 49 human ZBTB genes, we identify that BCL6 is req...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-77053 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
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