Sort   by:  
 Page size 
ProteomicsFungal extract screening reveals malformin C to preferentially kill glioblastoma cells via concerted induction of proteotoxic stress and autophagic flux blockade
Azide-labelled malformin C or DMSO was incubated with protein lysate from patient derived glioblastoma stem-like cells (NCH421k), and a pulldown of the compound with Dibenzocyclooctyne (DBCO) agarose was performed in order to identify interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046258 | Pride
Target deconvolution Glioblastoma Stem cells 
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to drug exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three drugs, acetaminophen (APAP), cyclosporine A (CSA) and valproic acid (VPA), that have a high liability for drug-induced liver injury. To ...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12668 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of temporal concentration responses to cosmetic ingredients exposures in PHH and HepaRG cells
For the purpose of mechanism-based risk assessment, we investigated temporal concentration-dependent responses in cultures of PHH and HepaRG cells exposed to three cosmetics ingredients, 2,7-naphthalenediol (NPT), triclosan (TCS) and butylated hydroxytoluene (BHT), that are suspected to have liver i...
ORGANISM(S): synthetic construct 
2024-03-01 | E-MTAB-12677 | biostudies-arrayexpress
TranscriptomicsRNA seq of rectal tumour tissue and paired healthy tissue, with EpCAM purification
Tumour tissue was immediately obtained post-surgery along with paired healthy tissue near (<2cm from tumour margin) and far (>10cm) from the tumour site. Each tissue was dissociated and stained with flow cytometry antibodies and sorted by FACS into Live/Dead-negative EpCAM-positive CD3-negative popu...
ORGANISM(S): Homo sapiens 
2020-02-27 | E-MTAB-8803 | biostudies-arrayexpress
ProteomicsAffinity Purification Mass Spectrometry of protein protein interactors with alternatively-spliced Uromodulin
We identified an alternatively spliced UMOD which is uniquely localized intracellularly. This intracellular isoform enhanced mitochondrial function. To understand its molecular mechanism, we performed affinity-purification coupled to mass spectrometry using MDCK cell lysate expressing UMOD variant. ...
ORGANISM(S): Canis Lupus Familiaris (ncbitaxon:9615) Homo Sapiens (ncbitaxon:9606) 
2024-03-15 | MSV000094329 | MassIVE
GenomicsUC
WTCCC2 project Ulcerative Colitis (UC) samples
EGAD00000000025 | EGA
GenomicsWTCCC2 case-control study for Ulcerative Colitis
WTCCC2 project genome-wide case-control association study for Ulcerative Colitis (UC) using the 1958 British Birth Cohort and the UK National Blood Service collections as controls.
EGAS00000000084 | EGA
GenomicsWTCCC2 project controls - 1958 British Birth Cohort and National Blood Service
WTCCC2 project controls - 1958 British Birth Cohort and National Blood Service
EGAS00000000028 | EGA
UnknownEmergent high fatality lung disease in systemic juvenile arthritis.
Not available
S-EPMC7065839 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
Sort   by:  
 Page size