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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsDBA2J Phosphatidylinositol Analysis
Not available
ORGANISM(S): Mus musculus 
ST000581 | MetabolomicsWorkbench
MetabolomicsMMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA), is central in driving ferroptosis. Here, we reveal that ...

2023-09-06 | MTBLS8280 | MetaboLights
TranscriptomicsLack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish
cdipt is an essential gene in the synthesis of phosphatidylinositol (PtdIns) in the zebrafish, Danio rerio. The zebrafish mutant cdipt^hi559Tg (ZL782) carries a retroviral insertion which inactivates cdipt. Homozygous mutants exhibit hepatocellular endoplasmic reticulum (ER) stress and non-alcoholic...
ORGANISM(S): Danio rerio 
2011-05-09 | E-GEOD-17711 | biostudies-arrayexpress
TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-20015 | biostudies-arrayexpress
ProteomicsLabel-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains. Label-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains.
The project is aimed at characterizing the effect of loss of phosphatidylinositol 3- phosphate kinase (CgVps34) on the plasma membrane proteome of Candida glabrata.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042056 | Pride
Plasma membrane (pm) Pi3k (phosphatidylinositol 3- phosphate kinase) Candida glabrata Label-free quantitative proteome analysis 
ProteomicsAdenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling
The human adenovirus serotype 5 E4ORF1 (Ad5E4ORF1) protein promotes primary endothelial cell survival and angiocrine functions by hijacking the cellular phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. However, the mechanism by which E4ORF1 activates PI3K in vascular cells remains largely...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069348 | Pride
Adenovirus  akt  angiogenesis  dlg1  e4orf1  endothelium  phosphatidylinositol-3-kinase. 
GenomicsInactivation of phosphatidylinositol 4-kinase IIIalpha (PI4KA) by GSK-A1 inhibitor in HEK293 cells
Inactivation of phosphatidylinositol 4-kinase IIIalpha (PI4KA) by GSK-A1 inhibitor in HEK293 cells
PRJNA1297159 | ENA
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
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