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TranscriptomicsLack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish
cdipt is an essential gene in the synthesis of phosphatidylinositol (PtdIns) in the zebrafish, Danio rerio. The zebrafish mutant cdipt^hi559Tg (ZL782) carries a retroviral insertion which inactivates cdipt. Homozygous mutants exhibit hepatocellular endoplasmic reticulum (ER) stress and non-alcoholic...
ORGANISM(S): Danio rerio 
2011-05-09 | E-GEOD-17711 | biostudies-arrayexpress
MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
UnknownStructural basis for phosphatidylinositol-phosphate biosynthesis.
Not available
S-EPMC4634129 | biostudies-literature
GenomicsErgosterol-Induced Immune Response in Barley Involves Phosphorylation of Phosphatidylinositol Phosphate Metabolic Enzymes and Activation of Diterpene Biosynthesis
Ergosterol-Induced Immune Response in Barley Involves Phosphorylation of Phosphatidylinositol Phosphate Metabolic Enzymes and Activation of Diterpene Biosynthesis
PRJNA1178109 | ENA
UnknownStructural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria.
Not available
S-EPMC7483940 | biostudies-literature
ProteomicsRegulation of the microsomal proteome by salicylic acid and deficiency of phosphatidylinositol‐4‐kinases β1 and β2 in Arabidopsis thaliana
Phosphatidylinositol-4-kinases β1 and β2 (PI4Kβ1/PI4Kβ2), which are responsible for phosphorylation of phosphoinositol to phosphatidylinositol-4-phosphate, have an important role in vesicular trafficking in plants. Moreover, PI4Kβ1/PI4β2 negatively regulate biosynthesis of phytohormone salicylic aci...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-02-24 | PXD019737 | Pride
Arabidopsis thaliana Microsomal fraction Phosphatidylinositol-4-kinases β1 and β2 Salicylic acid Label-free quantification Lc-ms/ms 
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
TranscriptomicsErgosterol-Induced Immune Response in Barley Involves Phosphorylation of Phosphatidylinositol Phosphate Metabolic Enzymes and Activation of Diterpene Biosynthesis
Lipids play crucial roles in plant-microbe interactions, functioning as structural components, signaling molecules, and microbe-associated molecular patterns (MAMPs). However, the mechanisms underlying lipid perception and signaling in plants remain largely unknown. Here, we investigate the immune r...
ORGANISM(S): Hordeum vulgare 
2025-01-31 | GSE280369 | GEO
UnknownIncreasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana.
Not available
S-EPMC4844314 | biostudies-literature
UnknownDrosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes.
Not available
S-EPMC10917494 | biostudies-literature
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