Phosphodiesterases

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Mutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling

Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...

ORGANISM(S): Cellular Organisms

2023-02-22 | PXD032173 | JPOST Repository

Tissue profiling of phosphodiesterases

We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. 24 human tissues plus one control pool were selected to investigate tissue-specific transcription and RNA splicing of the human ...

ORGANISM(S): Homo sapiens

2010-07-01 | E-GEOD-5983 | biostudies-arrayexpress

Homo sapiens

Tissue profiling of phosphodiesterases

PRJNA97467 | ENA

Phosphodiesterases Expression during Murine Cardiac Development.

Not available

S-EPMC7961729 | biostudies-literature

Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases.

Not available

S-EPMC3109409 | biostudies-literature

Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli.