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TranscriptomicsTargeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer
Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40564 | biostudies-arrayexpress
TranscriptomicsGene profiling of heart atria in PI3K and Mst1 mouse models
We used microarrays to detail genome-wide gene expression underlying cardiac myocyte pathologies and identified candidate genes and specific pathways affecting cardiac myopathies Keywords: transgenics, cardiac disease analysis Mouse heart atria were dissected for RNA extraction and hybridisation on...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-12420 | biostudies-arrayexpress
TranscriptomicsPDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
Although 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to PI3K-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces Myc ...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
ProteomicsPhosphoinositide 3-kinase regulates basal wild-type RAS signaling to confer resistance to KRAS inhibition
Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle. We show here that phosphoinositide 3-kinase (PI3K) plays a major role in this resistance through up...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD065233 | Pride
Phosphoinositide 3-kinase Proteomics Ras signaling Kras 
GenomicsGlycolysis Promotes Phosphoinositide 3-Kinase Signaling In Support of T Helper 17 Cell-Mediated Autoimmunity
Glycolysis Promotes Phosphoinositide 3-Kinase Signaling In Support of T Helper 17 Cell-Mediated Autoimmunity
PRJNA692622 | ENA
TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-20015 | biostudies-arrayexpress
TranscriptomicsGene expression profiling upon PI3K inhibition using different inhibitors
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. Therefore, the development of PI3K inhibitors has attracted much attention. We previously described the pyrazolopyrimidine derivative ETP-45658 as a potent inhibitor of P...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-56579 | biostudies-arrayexpress
GenomicsLong non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling
Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling
PRJNA871030 | ENA
ProteomicsStructure of the phosphoinositide 3-kinase p110-p101 complex reveals molecular mechanism of GPCR activation
The class IB phosphoinositide 3-kinase (PI3K), PI3K, is a master regulator of immune cell function, and is a promising drug target for both inflammatory diseases and cancer. Critical to PI3K function is the association of the p110 catalytic subunit to either a p101 or p84 regulatory subunit, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025209 | Pride
Hdx Cryo-em Gpcr Pik3g 
UnknownInhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).
Not available
S-EPMC10392309 | biostudies-literature
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