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ModelsKoch2021 - Phospholamban_network
Ordinary differential equation model of the micropeptide phospholamban and the control of its phosphorylation status at serine 16 in the context of beta-adrenergic stimulation. This model is the first detailed kinetic model of the phospholamban subnetwork of the beta-adrenergic signaling pathway and...
2021-07-19 | MODEL2011110001 | BioModels
Manuscript Accepted 
UnknownPhospholamban R14del disease: The past, the present and the future.
Not available
S-EPMC10151546 | biostudies-literature
ProteomicsProtein aggregation is an early manifestation of phospholamban p.(Arg14del)-related cardiomyopathy
Background: The p.(Arg14del) pathogenic variant (R14del) of the phospholamban (PLN) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardi...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD024594 | Pride
Inherited cardiomyopathy Heart failure Phospholamban Protein aggregation 
UnknownMyofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy.
Not available
S-EPMC9917359 | biostudies-literature
GenomicsImpaired Right Ventricular Calcium Cycling Is an Early Risk 2 Factor in R14del-Phospholamban Arrhythmias
Impaired Right Ventricular Calcium Cycling Is an Early Risk 2 Factor in R14del-Phospholamban Arrhythmias
PRJNA726640 | ENA
UnknownPhospholamban overexpression in transgenic rabbits.
Not available
S-EPMC2366038 | biostudies-literature
UnknownArrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.
Not available
S-EPMC8456417 | biostudies-literature
TranscriptomicsImpaired Right Ventricular Calcium Cycling Is an Early Risk 2 Factor in R14del-Phospholamban Arrhythmias 
We utilized humanized wild-type and R14 deletion (R14del) phospholamban (PLN) knock-in mice to determine the role of the inherited PLN-R14del on malignant right ventricular arrhythmias.
ORGANISM(S): Mus musculus 
2021-07-27 | GSE173684 | GEO
UnknownImpaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias.
Not available
S-EPMC8226909 | biostudies-literature
GenomicsCorrection of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy [Exome-Seq]
Phospholamban R14del mutazion (PLN-R14del) has been identified in a large family pedigree in which heterozygous carriers exhibited inherited dilated cardiomyopathy (DCM) and death by middle age. To better understand the causal link between the mutations in PLN and DCM pathology, we derived induced p...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-65762 | biostudies-arrayexpress
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