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MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
MetabolomicsTargeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specific role in...
2025-06-19 | MTBLS12324 | MetaboLights
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-01 | E-GEOD-35745 | biostudies-arrayexpress
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-23 | E-GEOD-35677 | biostudies-arrayexpress
Transcriptomicsedelfosine and wortmannin effect at 22°c and 4°c-PI4-kinase and phospholipase C signaling in cold response
rs09-04_plc_2 - edelfosine and wortmannin effect at 22°c and 4°c - Is there an overlap between PI4-kinase and phospholipase C signaling in cold response ? - Experiments were carried out with Columbia suspension cells. Cells were treated or not with edelfosine (PLC inhibitor) or wortmannin (PI4-kinas...
ORGANISM(S): Arabidopsis thaliana 
2010-08-01 | E-GEOD-19850 | biostudies-arrayexpress
TranscriptomicsMisregulation of the broad-range phospholipase C activity increases the susceptibility of Listeria monocytogenes to intracellular killing by neutrophils
Listeria monocytogenes is a facultative intracellular bacterial pathogen that tightly regulates the activities of various virulence factors during infection. A mutant strain (the plcBM-NM-^Tpro mutant) that has lost the ability to control the activity of a phospholipase C (PC-PLC) is attenuated a hu...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49820 | biostudies-arrayexpress
TranscriptomicsThe effect of PLC inhibitor on cold responsive transcriptome.
Identification of genes induced with the cold via inhibition of the phospholipase C - To answer this question we chose a pharmacological approach. We decided to use molecules that are going to inhibit PLC. U73343 is an inactive homolog of U73122 (inhibitor of the phospholipase C pathway). Keywords: ...
ORGANISM(S): Arabidopsis thaliana 
2010-05-22 | E-GEOD-13295 | biostudies-arrayexpress
ProteomicsA chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions
Alcohol consumption leads to formation of phosphatidylethanol (PEth) via the transphosphatidylation activity of phospholipase D (PLD) enzymes. Though this non-natural phospholipid routinely serves as a biomarker of chronic alcoholism, its pathophysiological roles remain unknown. We use a minimalist ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD029749 | Pride
Cuaac Basigin Phosphatidyl ethanol Phosphatidic acid Diazirene Photoaffinity label Click chemistry Phospholipase d Phosphatidyl alcohol 
Transcriptomicsedelfosine and wortmannin effect at 22°c and 4°c-PI4-kinase and phospholipase C signaling in cold response
rs09-04_plc_2 - edelfosine and wortmannin effect at 22°c and 4°c - Is there an overlap between PI4-kinase and phospholipase C signaling in cold response ? - Experiments were carried out with Columbia suspension cells. Cells were treated or not with edelfosine (PLC inhibitor) or wortmannin (PI4-kinas...
ORGANISM(S): Arabidopsis thaliana 
2010-08-01 | GSE19850 | GEO
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-01 | GSE35745 | GEO
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