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ProteomicsQuantitative chemical proteomic profiling of phosphoprotein phosphatases
We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhi...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) Candida Albicans (ncbitaxon:5476) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) Schizosaccharomyces Pombe (ncbitaxon:4896) 
2017-07-07 | MSV000081226 | MassIVE
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
ProteomicsA phosphoproteomic and transcriptomic analysis of carnosine’s action on signaling in glioblastoma U87-MG cells
Previous studies demonstrated that carnosine affects signaling molecules of different pathways in a number of experimental models. However, the primary targets of carnosine are still unknown and its effect on complex signal transduction has not been revealed. This is especially the case for pathways...
ORGANISM(S): Homo sapiens 
2019-11-30 | E-MTAB-6455 | biostudies-arrayexpress
UnknownContext Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Not available
S-EPMC5279869 | biostudies-literature
UnknownFibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling.
Not available
S-EPMC5216754 | biostudies-literature
TranscriptomicsAn integrated global analysis of compartmentalized HRAS signaling
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens 
2019-03-12 | E-MTAB-7672 | biostudies-arrayexpress
UnknownRapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays.
Not available
S-EPMC4626792 | biostudies-literature
ProteomicsEvaluation of quantification and normalization strategies for phosphoprotein phosphatase affinity proteomics: application to breast cancer signaling
Accurate quantification of proteomics data is essential for correctly characterizing signaling processes. We have recently developed a chemical proteomic strategy, phosphatase inhibitor beads and mass spectrometry (PIB-MS), to investigate endogenous phosphoprotein phosphatase (PPP) dephosphorylation...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-29 | MSV000090020 | MassIVE
UnknownA Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks.
Not available
S-EPMC3694890 | biostudies-literature
TranscriptomicsFGF21-Induced Gene Expression in Mouse Adipose Tissues
FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. In the current study, we investigated the signal transduction pathways downstream of FGF21 following acute administration of the growth factor to mice. Focusing on adipo...
ORGANISM(S): Mus musculus 
2013-11-18 | E-GEOD-44095 | biostudies-arrayexpress
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