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MetabolomicsGut microbiota-derived deoxycholic acid promotes pancreatic regeneration following acute pancreatitis via Reg3a signaling pathway

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

2026-03-08 | MTBLS14000 | MetaboLights
TranscriptomicsHuman colorectal cancer cell lines treated with several inhibitors of PI3Kinase AKT signaling pathway
Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contributes to onc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18005 | biostudies-arrayexpress
OtherConvergence of ubiquitylation and phosphorylation signaling in rapamycin-treated yeast cells.
Data from ProteomeXchange, PXD ID: PXD000554. Experiment: SILAC_SC_Rap048_2ndrep_SCX, file: folder summary. Published as part of Mol Cell Proteomics. 2014 Aug;13(8):1979-92 . From the Abstract: {{i}} ... Here, we used a mass-spectrometry-based proteomics approach for the parallel quantification of ...
ORGANISM(S): Yeast 
GPM32320003896 | GPMDB
Resource Reanalysis 
MetabolomicsExercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

OBJECTIVE: To explore the cardioprotective effects of exercise-derived β-aminoisobutyric (BAIBA) on cardiomyocyte apoptosis and energy metabolism in a rat model of heart failure (HF).

METHODS: In male Sprague-Dawley rats (8-week-old), myocardial infarction ...

2022-03-08 | MTBLS3927 | MetaboLights
TranscriptomicsSurvival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3b phosphorylation
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report here a novel finding that PDGF...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-19207 | biostudies-arrayexpress
TranscriptomicsEcdysone signaling and transcript signature in Drosophila cells resistant against methoxyfenozide
Methoxyfenozide (RH-2485) represents the group of non-steroidal ecdysteroid agonists with a dibenzoylhydrazine structure, that are used as novel biorational insecticides in the control of insect pests. Here we report on the selection of Drosophila melanogaster S2 cells for resistance to inhibition o...
ORGANISM(S): Drosophila melanogaster 
2010-11-08 | E-GEOD-17748 | biostudies-arrayexpress
TranscriptomicsReconstruction of signaling networks regulating fungal morphogenesis by transcriptomics
Reconstruction of signaling networks regulating fungal morphogenesis by the expression profiling of wild-type and the temperature sensitive morphological ramosa-1 mutant. Aspergillus niger wildtype versus Ramosa mutant for 1h at 37 under controlled growth condition in 5L bioreactor
ORGANISM(S): Aspergillus niger 
2010-05-05 | E-GEOD-17641 | biostudies-arrayexpress
ProteomicsInvestigation of Proteomic and Phosphoproteomic Responses to Signaling Network Perturbations Reveals Functional Pathway Organizations in Yeast
Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylatio...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-15 | PXD015575 | Pride
Streamlined tandem mass tag strategy Proteomics Protein regulation network Multi-notch ms3 Protein kinases and phosphatases Phosphoproteomics Phosphorylation signaling pathway organization Phosphorylation regulation network 
TranscriptomicsIdentification of immediate early transcriptional targets of ephrin-B1 forward signaling
The goal of this study was to identify immediate early transcriptional targets of ephrin-B1 forward signaling that are relevant to palatogenesis. The Ephs compose a family of receptor tyrosine kinase signaling molecules that can be activated by their cognate ligands, the ephrins. Despite the import...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-23539 | biostudies-arrayexpress
TranscriptomicsProtection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress
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