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Bacterial pathogens rapidly change and adapt their proteome to cope with the environment in host cells and secret effector proteins to hijack host targets to ensure their survival and proliferation during infection. Excessive host proteins make it difficult to profile pathogens’ proteome dynamics by...
ORGANISM(S): Homo sapiens (Human) 
2023-01-28 | PXD033036 | Pride
Multicellular organisms are composed of many tissue types that have distinct morphologies and functions, which are largely driven by specialized proteomes and interactomes. To define the proteome and interactome of a specific type of tissue in an intact animal, we developed a localized proteomics ap...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD048632 | Pride
Cold stress impedes the growth and development of plants, restricts the geographical distribution of plant species, and impacts crop productivity. In this study, we analyzed the Arabidopsis thali-ana transcriptome to identify genes with differential expression (DEGs) in 14-day-old plantlets exposed ...
ORGANISM(S): Arabidopsis thaliana 
2024-10-19 | GSE278815 | GEO
Transcriptome analysis reveals genes responsive to three low-temperature treatments in Arabidopsis thaliana
Genetic studies have identified numerous sequence-specific transcription factors that control development, yet little is known about their in vivo distribution across animal genomes. We determine the genome-wide occupancy of the dorsoventral determinants Dorsal, Twist and Snail in the Drosophila emb...
ORGANISM(S): Drosophila melanogaster 
Genetic studies have identified numerous sequence-specific transcription factors that control development, yet little is known about their in vivo distribution across animal genomes. We determine the genome-wide occupancy of the dorsoventral determinants Dorsal, Twist and Snail in the Drosophila emb...
ORGANISM(S): Drosophila melanogaster 
The aim of this study was to characterize the effect of phenformin on human melanoma cells at the transcritpional level. Experimentally, A375 cells have been treated or untreated with 0.5mM phenformin for 72h, then lysed for RNA isolation.
ORGANISM(S): Homo sapiens 
The aim of this study was to generate an easy-to-reproduce, on-off in vitro model of metabolic switch in melanoma that can be used as a tool for the study of metabolic reprogramming under stress conditions, therapeutic pressure or microenvironmental changes. Experimentally, we forced melanoma cells...
ORGANISM(S): Homo sapiens 
We apply the cellular reprogramming experimental paradigm to two disorders caused by symmetrical copy number variations (CNV) of 7q11.23 and displaying a striking combination of shared as well as symmetrically opposite phenotypes: Williams Beuren syndrome (WBS) and 7q microduplication syndrome (7dup...
ORGANISM(S): Homo sapiens 
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