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Photoaging is cumulative damage that is caused by chronic, repeated solar radiation exposure to skin. Its molecular mechanisms are poorly understood at the level of global gene expression.This study set out to uncover genes and functional modules involved in photoaging at the level of transcription,...
ORGANISM(S): Homo sapiens 
Identifying ST6GAL1 as a novel factor for human dermal fibroblast photoaging
The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis
Due to increasing global UV exposure from environmental changes and lifestyle factors, understanding the molecular mechanisms of photoaging is critical in dermatological research. This study addresses the underexplored role of glycosylation in dermal fibroblast photoaging by establishing an in vitro...
ORGANISM(S): Homo sapiens 
2026-09-02 | GSE329475 | GEO
Human skin is composed of the cell-rich epidermis, the extracellular matrix (ECM) rich dermis, and the hypodermis. Within the dermis, a dense network of ECM proteins provides structural support to the skin and regulates a wide variety of signaling pathways which govern cell proliferation and other c...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD015982 | Pride
Genomics
UVB-induced skin photoaging
Background: N6-Methyladenosine (m6A) methylation, a common form of RNA modification, play an important role in the pathogenesis of various diseases and in the ontogeny of organisms. Nevertheless, the precise function of m6A methylation in photoaging remains unknown. Objectives: This study aims to in...
ORGANISM(S): Mus musculus 
2024-07-16 | GSE268348 | GEO
YAP-TEAD complex inhibits photoaging via transcriptional regulation of homologous recombination repair in mouse (smal) - miRNA-seq
YAP-TEAD complex inhibits photoaging via transcriptional regulation of homologous recombination repair in mouse (smal) - lncRNA-seq
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