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TranscriptomicsControlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions
In this study, the relationship between pericellular and gas phase oxygen concentration in cell culture was examined. To this end, we examined the influence of cellular oxygen consumption on primary human hepatocyte culture in physioxic (6% O2) and normoxic (18.6% O2) conditions. To understand how p...
ORGANISM(S): Homo sapiens 
2024-06-27 | GSE270930 | GEO
GenomicsControlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions
Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions
PRJNA1129053 | ENA
UnknownPhysioxia improves the selectivity of hematopoietic stem cell expansion cultures.
Not available
S-EPMC10345863 | biostudies-literature
UnknownPhysioxia rewires mitochondrial complex composition to protect stem cell viability.
Not available
S-EPMC11466565 | biostudies-literature
UnknownPhysioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis.
Not available
S-EPMC6721827 | biostudies-literature
ProteomicsMemory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions
Memory CD8+ T cells are indispensable for maintaining long-term immunity against intracellular pathogens and tumors. Despite their presence in oxygen-deprived tissues of infection sites or tumors, the impact of local oxygen pressure on memory CD8+ T cells has remained largely unclear. We sought to e...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-01 | PXD032236 | Pride
Cytotoxic t cells Cd8+ memory t cells Physioxic cell culture Tcr-mediated activation T cell metabolism 
ProteomicsEffect of oxygen tension on MMTV-PyMT tumor cell kinome
Solid tumors are characterized by significantly lower oxygen (O2) levels. Despite this fact, routine preclinical cancer studies are performed under ambient O2 conditions. We have developed an experimental approach that allows us to collect, process and evaluate cancer and non-cancer cells under phys...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-08 | PXD046005 | Pride
Ambient Breast cancer Kinase inhibitor beads Physioxia Lapatinib 
UnknownNeurogenic and Neuroprotective Potential of Stem/Stromal Cells Derived from Adipose Tissue.
Not available
S-EPMC8231154 | biostudies-literature
GenomicsOxygen tension-dependent variability in the cancer cell kinome and response to combination therapies
Oxygen tension-dependent variability in the cancer cell kinome and response to combination therapies
PRJNA1023981 | ENA
ProteomicsProteomic-based analysis of hypoxia and physioxia responsive proteins and pathways in DLBCLProteomic-based analysis of hypoxia and physioxia responsive proteins and pathways in DLBCL
Hypoxia is damaging to normal cells as well as cancerous cells. Reports assessing hypoxia- and physioxia-induced global proteome changes in lymphoma are lacking. Here, we sought to explore how the proteome of diffuse large B-cell lymphoma (DLBCL) changes when cells are exposed to the acute hypoxic s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026726 | Pride
Hypoxia  physioxia  diffuse large b-cell lymphoma (dlbcl)  b-cell non-hodgkin lymphomas  label-free quantitative proteomics  protein-protein interaction network (ppin)  cell stress 
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