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TranscriptomicsGene expression profiling upon PI3K inhibition using different inhibitors
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. Therefore, the development of PI3K inhibitors has attracted much attention. We previously described the pyrazolopyrimidine derivative ETP-45658 as a potent inhibitor of P...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-56579 | biostudies-arrayexpress
TranscriptomicsExpression data from control and Med12-deficient hematopoietic stem cells and progenitors
Hematopoietic stem cells and progenitors from controls and Med12Flox; mxCre mice treated with pI:pC 4 days afters injection were sorted and Micrroarray Affymetrix mouse 430.2 platform. Results provide insight into the gene signatures regulated by Med12 that are essential for the homeostasis of the h...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-75879 | biostudies-arrayexpress
GenomicsHistone chromatin modifications in control and Med12-deficient mouse HSPCs
Using iChIP, we map H3K27Ac, H3K4me3 and H3K4me1 in small populations (HSPCs) in the presence or absence of Med12 and identify affected super-enhancers. iChIP was performed using previously published protocols (Lara-Astiaso et al, 2014 Immunogenetics. Chromatin state dynamics during blood formation ...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-76052 | biostudies-arrayexpress
GenomicsRegulation of enhancer dynamics by MED12
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-76055 | biostudies-arrayexpress
UnknownDesign, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype.
Not available
S-EPMC12175570 | biostudies-literature
ProteomicsMyotubularin-related proteins control abscission_StDenis_MTMR_P84_VS6-7-8-11-12
This submission is part of the mass spectrometry datasets for the manuscript by St-Denis et al. entitled: Myotubularin-related proteins 3 & 4 interact with PLK1 and CEP55 to control CEP55 recruitment to the midbody and ensure proper abscission. This submission contains 82 RAW files and 82 mgf files...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-10-30 | MSV000078915 | MassIVE
TranscriptomicsA promoter DNA demethylation landscape of human hematopoietic differentiation
Global mechanisms defining the gene expression programs specific for hematopoiesis are still not fully understood. Here, we show that promoter DNA demethylation is associated the activation of hematopoietic-specific genes. Using genome-wide promoter methylation arrays, we identified 694 hematopoie...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30090 | biostudies-arrayexpress
TranscriptomicsGene expression profile of hemocytes from Manila clam (Venerupis philippinarum) after a Perkinsus olseni challenge using an immune-enriched oligo-microarray
Parasites of the genus Perkinsus spp. cause high mortalities and economic losses to the most noticeable bivalves produced in the worldwide aquaculture. In this study, we analyze how P. olseni influences the gene expression profiles of hemocytes from Manila clam (Venerupis philippinarum) using experi...
ORGANISM(S): Ruditapes philippinarum 
2015-07-31 | E-GEOD-59399 | biostudies-arrayexpress
UnknownAn international consensus on the design of clinical trials for advanced combination treatment (ACT) in inflammatory bowel disease.
Not available
S-EPMC12593430 | biostudies-literature
TranscriptomicsThe transcriptome of human iPSC-derived cardiomyocytes
Currently, cardiomyocytes differentiated from human induced pluripotent stem cells (iPSCs) are routinely generated for disease research and drug development as an alternative to animal models. Although iPSC-derived cardiomyocytes (iPSC-CMs) are generally assumed to resemble myocytes in the fetal hea...
ORGANISM(S): Homo sapiens 
2025-03-30 | E-MTAB-13757 | biostudies-arrayexpress
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