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MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
ProteomicsMitochondrial mutant Caenorhabditis elegans Proteome
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the proteomic landscape of Caenorhabditis elegans with severe mitoch...
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | PXD011851 | Pride
Metabolism Caenorhabditis elegans Insulin signaling Complex i Mitochondria Mitochondrial deficiency Iis 
ProteomicsMitochondrial mutant Caenorhabditis elegans phosphoproteome
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the phosphoproteomic landscape of Caenorhabditis elegans with severe...
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | PXD011859 | Pride
Metabolism Caenorhabditis elegans Insulin signaling Complex i Mitochondria Mitochondrial deficiency Iis 
TranscriptomicsFunctional characterization of a Drosophila melanogaster mitochondrial deoxynucleotide transporter dRIM2.
We have studied the deoxynucleotide transport in Drosophila melanogaster. On the basis of homology with the S. cerevisiae RIM2 gene, encoding a pyrimidine deoxynucleotide carrier (Marrobbio et al. 2006), the CG18317 gene (dRIM2) in the fruit fly may code for a deoxynucleotide carrier. We demonstrate...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-48012 | biostudies-arrayexpress
UnknownMulti-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction
Not available
S-SCDT-EMBOJ-2018-99558 | biostudies-other
ProteomicsGut metaproteome of COVID-19 peadiatric patients
Stools from paediatric patients with COVID-19 were compared with age- and gender-matched healthy subjects to understand the functional roles of the gut microbial community in etiopathogenetic mechanisms of the disease trying to unveil new therapeutic targets.
ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606) 
2023-08-11 | MSV000092639 | MassIVE
ProteomicsActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble alpha-synuclein (alpha-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well- documented that the reversible liquid-liquid phase separation of alpha-Syn can modulate synapti...
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans 
2025-03-22 | PXD050719 | JPOST Repository
Unknowncest-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants
Not available
S-SCDT-EMBOR-2021-52606V1 | biostudies-other
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