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TranscriptomicsGenome-wide analysis of whole transcriptome in E(z) temperature sensitive cells [RNA-Seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-61307 | biostudies-arrayexpress
TranscriptomicsGene expression changes as a result of E-cadherin loss in an isogenic non-malignant MCF10A and MCF10A CDH1-/- breast cells
Background: E-cadherin is an adherens junction protein that forms homophilic intercellular contacts in epithelial cells while also interacting with the intracellular cytoskeletal networks. It has roles including establishment and maintenance of cell polarity, differentiation, migration and signallin...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-59317 | biostudies-arrayexpress
UnknownHLA-H: Transcriptional Activity and HLA-E Mobilization.
Not available
S-EPMC6978722 | biostudies-literature
GenomicsExome sequencing in classic Hairy cell leukaemia reveals widespread variation in acquired somatic mutations between individual tumours apart from the signature BRAF V(600)E lesion
Whole exome sequencing of 5 HCLc tumor-germline pairs. Genomic DNA from HCLc tumor cells and T-cells for germline was used. Whole exome enrichment was performed with either Agilent SureSelect (50Mb, samples S3G/T, S5G/T, S9G/T) or Roche Nimblegen (44.1Mb, samples S4G/T and S6G/T). The resulting exom...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-MTAB-4313 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Drosophila plasmatocyte mosaics which lack PRC2/H3K27me3
Genetic mosaics were induced in 3rd instar larvae by heatshock to generate H3K27R mutants, Su(z)12 mutants or E(z) mutants
ORGANISM(S): Drosophila melanogaster 
2022-05-31 | E-MTAB-10762 | biostudies-arrayexpress
ProteomicsGlobal proteome changes of normal NIH 3T3 versus Ras-transformed NIH cells treated with 3 different Hsp90 inhibitors (geldanamycin, PU-H71 and pochoxime A)
Heat shock protein 90 (Hsp90) is a major hub in the protein network that maintains cellular homeostasis and function. The qualitative and quantitative changes and rewiring of this protein network in tumor cells make them vastly dependent on Hsp90, and as a consequence its inhibition creates a profou...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-11 | PXD009055 | JPOST Repository
GenomicsChromosome 11 analysis in myeloid malignancies - WES
Blood samples from patients with myeloid malignancies were analyzed using whole exome sequencing (WES). Data set from genotyping by microarray of the same samples has been deposited in ArrayExpress under accession number E-MTAB-1845 (https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1845/).
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MTAB-1850 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and delta-sba1 yeast treated with radicicol to study gene regulation by sba1
We wanted to study regulation of gene regulation by sba1 (ortholog of mammalian p23) in yeast. sba1/p23 binds to Hsp90 and acts as a co-chaperone. We have a small molecule, radicicol, an analog of geldanamycin to inhibit the binding of p23 to Hsp90. Consequently, we have analyzed the gene expression...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-14 | E-TABM-573 | biostudies-arrayexpress
GenomicsAuthentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1
Whole genome sequencing (WGS) from snap-frozen oesophageal tumour tissue and germline nucleic acids isolated from peripheral blood mononuclear cells (PBMC) was performed as part of the International Cancer Genome Consortium project and OCCAMS consortium (1,2). Filtered read sequences were mapped to ...
ORGANISM(S): Homo sapiens 
2016-09-09 | E-MTAB-4600 | biostudies-arrayexpress
GenomicsUsf1, a Suppressor of the Circadian Clock Mutant, Reveals the Nature of the DNA-binding of the CLOCK:BMAL1 complex in mice
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockM-NM-^T19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockM-NM-^T19 mutatio...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-44609 | biostudies-arrayexpress
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