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ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
GenomicsLatent enhancers unveiled by stimulation expand and adapt the available cis-regulatory repertoire (FAIRE-seq)
According to current models, transcription factors (TFs) activated by extracellular stimuli operate in the context of a pre-established enhancer repertoire induced and maintained by lineage-specific TFs. Here, we uncovered the existence of latent enhancers, defined as regions of the genome that in t...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-41677 | biostudies-arrayexpress
GenomicsLatent enhancers unveiled by stimulation expand and adapt the available cis-regulatory repertoire (ChIP-seq)
According to current models, transcription factors (TFs) activated by extracellular stimuli operate in the context of a pre-established enhancer repertoire induced and maintained by lineage-specific TFs. Here, we uncovered the existence of latent enhancers, defined as regions of the genome that in t...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-38377 | biostudies-arrayexpress
TranscriptomicsLatent enhancers unveiled by stimulation expand and adapt the available cis-regulatory repertoire (RNA-seq)
According to current models, transcription factors (TFs) activated by extracellular stimuli operate in the context of a pre-established enhancer repertoire induced and maintained by lineage-specific TFs. Here, we uncovered the existence of latent enhancers, defined as regions of the genome that in t...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-38371 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [4C]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66950 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66953 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-73021 | biostudies-arrayexpress
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