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UnknownDrug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Not available
S-EPMC6607015 | biostudies-literature
UnknownChemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain.
Not available
S-EPMC6037894 | biostudies-literature
TranscriptomicsActivating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1-ETO-induced DNA damage in human cells
REtr causes genomic instability in human CD34+ cells. Activated forms of c-KIT, like c-KIT(N822K), rescue the REtr-induced genomic instability by increasing the rate of DNA repair by homologous recombination. Human CD34+ hematopoietic progenitor cells were transduced with retroviral vectors encoding...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58041 | biostudies-arrayexpress
UnknownExcess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Not available
S-EPMC4854555 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis wild type and arrhythmic CCA1-34 line reveals that rhythmic growth is explained by coincidence between internal and external cues
Plant hypocotyls elongate in response to darkness. The response to darkness is gated by the circadian clock, such that wild-type plants (Col) only respond to darkness with growth once every 24 hours, whereas arrhythmic lines, such as CCA1-34, will respond to darkness with growth at any time of day....
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-6906 | biostudies-arrayexpress
UnknownSequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development.
Not available
S-EPMC5349780 | biostudies-literature
Transcriptomicsß-amylase1 mutant Arabidopsis plants show improved drought tolerance due to reduced starch breakdown in guard cells
In plants, drought stress is a major growth limiting factor causing cell water loss through open stomata. In this study, guard cell-specific transcripts from drought-stressed Arabidopsis plants were analyzed and a down-regulation of β-amylase 1 (BAM1) was found. In previous studies, BAM1 was shown t...
ORGANISM(S): Arabidopsis thaliana 
2015-06-30 | E-GEOD-66105 | biostudies-arrayexpress
UnknownLysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Not available
S-EPMC6684646 | biostudies-literature
TranscriptomicsAnalysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.
Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect ...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-GEOD-17046 | biostudies-arrayexpress
UnknownControl of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Not available
S-EPMC7249499 | biostudies-literature
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