Analysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.

ABSTRACT: Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect resulted from the IRA induced activation of the pleiotropic MAPKinase ERK1/2 signaling pathway, indicating that the IRA response extends beyond MMP-1. In the present study we have therefore assessed the IRA-induced transcriptom in primary human skin fibroblasts. Results: Microarray analysis revealed 599 transcripts to be regulated by physiologically relevant doses of IRA in primary human skin fibroblasts. The IRA induced transcriptom differed from changes known to be induced by UVB or UVA radi

ORGANISM(S): Homo sapiens

SUBMITTER: Christian Calles 

PROVIDER: E-GEOD-17046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress