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TranscriptomicsTelomeric repeats facilitate CENP-A incorporation via telomere binding proteins
The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress
TranscriptomicsA DNA polymerase ? accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast
Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms involved in the propagation of these structures remain elusive. Fission yeast centromeres are composed of two chromatin domains: the central CENP-ACnp1 kinetochore domain and flanking...
ORGANISM(S): Schizosaccharomyces pombe 
2008-07-22 | E-GEOD-11102 | biostudies-arrayexpress
TranscriptomicsFactors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast
Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found at all centromeres. However, the mechanisms that specify the locations at which CENP-A chromatin is assembled remain elusive in organisms with regional, epigenetically regulated centromeres. It is known that norma...
ORGANISM(S): Schizosaccharomyces pombe 
2015-02-19 | E-GEOD-66106 | biostudies-arrayexpress
TranscriptomicsPcs1 and Mde4 are inner centromere proteins required to prevent merotelic kinetochore orientation
Chromosome segregation depends on proper attachment of sister kinetochores to microtubules. Merotelic kinetochore orientation is an error which occurs when a single kinetochore is attached to microtubules emanating form opposite poles. Mechanisms preventing or correcting the merotelic attachment mus...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-10 | E-GEOD-5257 | biostudies-arrayexpress
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