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TranscriptomicsTranscription profiling of lung tissue from cardiac death and brain death donors, both pre and post transplant
Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. However, the pathogenetic consequences of retrieved lungs after DCD vs. DBD have not been clarified. We aimed to study...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-18995 | biostudies-arrayexpress
Transcriptomicsarray-CGH profiling of human neuroblastoma samples obtained from infants included in the INES99.1, INES99.2 and INES99.3 trials
In neuroblastoma (NB), the presence of segmental chromosome alterations (SCA) is associated with a higher risk of relapse, even when occurring together with numerical chromosome alterations (NCA). Furthermore, recent evidence shows that SCAs play a role in tumor progression. In order to analyze the ...
ORGANISM(S): Homo sapiens 
2011-12-07 | E-GEOD-26494 | biostudies-arrayexpress
ProteomicsA scalable multiplexed platform to accelerate protein interactome discovery
Chromatographic fractionation-mass spectrometry (CF-MS) allows for mapping native protein-protein interactions and macromolecular complexes on a proteome-scale but is tedious and resource intensive for comparative analysis. Here, we present a more parsimonious and reproducible multiplexing CF-MS pla...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD027704 | Pride
Ion-exchange chromatography Multiplex Breast cancer Protein-protein interaction Protein complex Network biology Interactome Systems biology Co-fractionation mass spectrometry Quantitative proteomics 
TranscriptomicsExpression data from different samples of a single ccRCC patient.
We have sampled several tumour regions from a single patient before and after everolimus treatment, including both primary and metastatic site samples to investigate intra-tumour heterogeneity. We selected 4 primary tumour regions, including a pre-treatment biopsy, and 1 metastatic region for expres...
ORGANISM(S): Homo sapiens 
2011-08-05 | E-GEOD-31232 | biostudies-arrayexpress
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
ProteomicsHuman Protein Complexes Project LTQ RAW FILES
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2012-10-16 | MSV000078257 | MassIVE
TranscriptomicsTranscription profiling of mouse skin carcinogenesis in FVB/N and Tg.Ac mice
Female FVB/N and Tg.Ac (hemizygotes) mice 3-5 weeks of age were purchased from Harlan UK and Taconic UK, respectively. The mice were contained in an isolator and maintained at 19C with 50% relative humidity and a 12-hour light-dark cycle. Following a 1 week acclimatisation period the dorsal skin o...
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-188 | biostudies-arrayexpress
TranscriptomicsMulti-region copy-number analysis
Intra-tumour heterogeneity (ITH) foster tumour adaptation and hamper the efficiency of personalised medicine approaches. We investigated the extent of ITH within individual clear cell renal cell carcinomas (ccRCC) by multi-region sampling and copy number analysis. We analyzed 63 tumour regions and 8...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-47077 | biostudies-arrayexpress
TranscriptomicsExpression data from different samples of a single ccRCC patient: 8 primary intra-tumor samples and 2 metastatic tumor samples
We have sampled several tumour regions from a single ccRCC patient after 6 weeks everolimus treatment, including both primary and metastatic site samples to investigate intra-tumour heterogeneity. We selected 8 samples from the primary tumour, and 2 samples from a chestwall metastatic site for expre...
ORGANISM(S): Homo sapiens 
2011-08-24 | E-GEOD-31610 | biostudies-arrayexpress
GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
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