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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
MetabolomicsMetabolomic profiling reveals the effects of early-life lactoferrin intervention on protein synthesis, energy production and antioxidative capacity in the liver of suckling piglets

The objective of this study was to reveal the effects of early life lactoferrin intervention on the liver metabolism in the suckling piglets. Sixty newborn piglets with an average initial body weight (BW) of 1.51 ± 0.05 kg were assigned to the control (CON) group and the lactoferrin (LF) group. P...

2022-03-01 | MTBLS2279 | MetaboLights
MetabolomicsComparative non-targeted metabolomic profiling of PEDV-infected versus uninfected neonatal piglets

Three-day-old piglets were orally inoculated with L. reuteri, with age-matched untreated piglets serving as controls. Five days post-inoculation, all piglets were challenged with PEDV. Jejunal contents were collected during acute infection for non-targeted metabolomic profiling.For non-disea...

2025-07-04 | MTBLS12632 | MetaboLights
MetabolomicsJejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets

BACKGROUND: Dietary intervention has been reported to improve intestinal health. The intestinal microbiota of newborn animals plays a fundamental role in the development of intestinal function and the innate immune system. However, little is currently known about dietary interven...

2020-06-05 | MTBLS1698 | MetaboLights
MetabolomicsMicrobiome and metabolome features in treatment of early weaned piglets via multi-omics integration analyses across cohorts

BACKGROUND: Diarrhea is common in infants, particularly, children less than 2 years old. Intractable or protracted infancy diarrhea is typically associated with feeding intolerance and malabsorption that is lethal for newborns. This study aimed to evaluate the effectiveness of ba...

2024-02-01 | MTBLS9292 | MetaboLights
MetabolomicsEngineered Bacillus subtilis WB600/ZD reduces post-weaning diarrhea in piglets by modulating gut microbiota and aryl hydrocarbon receptor (AHR) signaling

Post-weaning diarrhea (PWD) causes significant economic losses to the pig farming industry. Our previous study demonstrated that the engineered Bacillus subtilis WB600/ZD (an engineered Bacillus subtilis strain expressing the antimicrobial defensin peptide from Zophobas atratus), alleviates intes...

2025-08-15 | MTBLS12862 | MetaboLights
Metabolomicsengineered bacillus subtilis protect the weaned piglets from ETEC K88 infection
engineered bacillus subtilis protect the weaned piglets from ETEC K88 infection through improving serum metabolites, intestinal imcrobiota, antioxidant and immune activity.
2026-02-23 | MTBLS7587 | MetaboLights
MetabolomicsPlasma 1H-NMR metabolic and amino acid profiles of newborn piglets from two lines divergently selected for residual feed intake

Together with environmental factors, physiological maturity at birth is a major determinant for neonatal survival and postnatal development in mammalian species. Maturity at birth is the outcome of complex mechanisms of intra-uterine development and maturation during the end of gestation. In pig ...

2023-02-16 | MTBLS2137 | MetaboLights
MetabolomicsIntegrated Multi-omics Analysis Identifies PPAR Signaling Network Associations with Metabolic-Immune Dysregulation and Intestinal Injury in PDCoV-Infected Piglets

Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus that causes severe diarrhea and high mortality in neonatal piglets and has demonstrated the capacity to infect human cells. However, the host response networks that govern disease outcome remain poorly understood. Here, we perfor...

2026-04-15 | MTBLS14236 | MetaboLights
MetabolomicsEarly-Life Intervention with Lactobacillus reuteri Enhances Intestinal2 Barrier Function and Resilience in Suckling Piglets via Modulation of3 Gut Microbiota and Metabolites
Early-life nutritional interventions are pivotal for promoting piglet growth and health, particularly in reducing weaning-associated disorders. This study investigated the effects of early-life Lactobacillus reuteri (L.reuteri) supplementation on growth performance, immune function, intestinal morph...
2026-03-27 | MTBLS14164 | MetaboLights
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