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TranscriptomicsTranscriptional profiles of pilocytic astrocytoma
Pilocytic astrocytoma is the most common type of brain tumor in pediatric population, generally connected with favorable prognosis, although recurrences or dissemination sometimes are also observed. For tumors originating in supra- or infratentorial location different molecular background was sugges...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-73066 | biostudies-arrayexpress
TranscriptomicsThe mRNA and microRNA expression profile of the RNA-induced silencing complex in human U-87 astrocytoma cells and primary human astrocytes
mRNA and microRNA expression was examined in global cellular fractions and in RNA-induced silencing complex (RISC)-immunoprecipitated cell fractions in cultured primary human astrocytes (ScienCell) and in cultured human U-87 MG astrocytoma cells (ATCC). ABSTRACT: Background: GW/P bodies are cytoplas...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pilocytic astrocytoma to develop molecular signatures
Pilocytic astrocytomas (PAs) are the most common glioma in children. While many PAs; are slow growing or clinically indolent, others exhibit more aggressive features with tumor; recurrence and death. In order to identify genetic signatures that might predict PA clinical; behavior, we performed gene ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5675 | biostudies-arrayexpress
TranscriptomicsGene expression data from pilocytic astrocytoma tumour samples and normal cerebellum controls
Pilocytic astrocytomas (PA) are the most common brain tumor in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated protein kinase (MAPK) pathway, but little else is known about ...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-44971 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human juvenile pilocytic astrocytomas reveals two potential subgroups
Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella. The genes involved in neurogenesis, cell adhesion, synaptic transmission, centra...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12907 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for low-grade astrocytoma samples
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14960 | biostudies-arrayexpress
ProteomicsProteogenomics reveals two distinct biological pilocytic astrocytoma subgroups
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and driven by aberrant MAPK signaling, typically mediated by BRAF alterations. While five-year overall survival rates exceed 95%, tumor recurrence constitutes a major clinical challenge in incompletely resected tumors despite chemot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035773 | Pride
Lc-msms Pilocytic astrocytoma Brain tumour 
GenomicsRNA-sequencing of six Pilocytic astrocytoma tumors
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). These feat...
EGAS00001002149 | EGA
GenomicsMolecular refinement of pilocytic astrocytoma in adult patients
Molecular refinement of pilocytic astrocytoma in adult patients
PRJNA1023582 | ENA
GenomicsDATA_SET_ICGC_PedBrain_Tumor_Low-Grade_Astrocytoma_Study - samples
Pilot study Pilocytic Astrocytoma ICGC PedBrain, whole genome sequencing of 5 tumors and matched blood
EGAD00001000271 | EGA
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