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TranscriptomicsGene expression changes induced by the pan-PIM inhibitor ETP-39010 in 4 peripheral T cell lymphoma cell lines
Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. In these study we hypothesized that PIM kinases could be of therapeutic value in PTCL because we ...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-42595 | biostudies-arrayexpress
TranscriptomicsProviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation
The aim of the dataset was to study on genome-wide level the effect of PIM kinase (PIM1+PIM2+PIM3) knockdown in gene expression on early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) polarizing conditions. Total RNA from PIM1+PIM2+PIM3 siRNA treated cord bloo...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-40542 | biostudies-arrayexpress
GenomicsTranscriptome analysis PIM kinase inhibition vs degradation
Transcriptome analysis PIM kinase inhibition vs degradation
PRJNA994475 | ENA
ProteomicsPIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
Proteomic analysis revealed potential phospho-acceptor sites within Vpx by PIM3. HEK293 cells were transfected with plasmid vector encoding Vpx together with either empty vector or PIM3. Immunoprecipitated Vpx was subjected to liquid chromatography tandem-mass spectrometry.
ORGANISM(S): Homo Sapiens (human) 
2019-03-20 | PXD013154 | JPOST Repository
TranscriptomicsGene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased ...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-32018 | biostudies-arrayexpress
TranscriptomicsEffect of AZD1208 on gene expression in recurrent resistant Myc-CaP tumors grown in castrated mice.
AZD1208 is a novel PIM kinase inhibitor that we have shown inhibits tumorigenesis in tissue recombination models, Myc-CaP allograft models, and human prostate cancer xenografts. We sought to determine the intracellular pathways that are responsible for the anti-tumor effect. To this end we used the ...
ORGANISM(S): Mus musculus 
2014-12-24 | E-GEOD-59106 | biostudies-arrayexpress
GenomicsPIM Kinase Inhibitor AZD1208 Treats MYC-driven Prostate Cancer
PIM Kinase Inhibitor AZD1208 Treats MYC-driven Prostate Cancer
PRJEB5525 | ENA
TranscriptomicsERG deregulation induces PIM-1 over-expression and aneuploidy in prostate epitheilial cells
The ERG gene belongs to the ETS family of transcription factors and has been found involved in atypical chromosomal rearrangements in several cancers. To gain insight into the oncogenic activity of ERG, we compared the gene expression profile of NIH-3T3 cells stably expressing the coding regions of ...
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-32481 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis PIM kinase inhibition vs degradation
PIM kinases have important pro-tumorigenic roles and mediate several oncogenic traits, including cell proliferation, survival, and chemotherapeutic resistance. As a result, multiple PIM inhibitors have been pursued as investigational new drugs in cancer; however, response to PIM inhibitors in solid ...
ORGANISM(S): Homo sapiens 
2023-12-04 | GSE237256 | GEO
GenomicsPIM kinase inhibition in HCC xenograft
PIM kinase inhibition in HCC xenograft
PRJNA598723 | ENA
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