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TranscriptomicsTranscription profiling of Arabidopsis cell-sorted, hydrated pollen grains vs those of flowers, leaves, seedlings and siliques
Upon germination, pollen forms a tube that elongates dramatically through female tissues in order to reach and fertilize ovules. While essential for the life cycle of higher plants, the genetic basis underlying most of the process is not well understood. We used Affymetrix Arabidopsis ATH1 Genome Ar...
ORGANISM(S): Arabidopsis thaliana 
2005-06-01 | E-MEXP-285 | biostudies-arrayexpress
TranscriptomicsRNA-seq of engineered K562 cell line by CRISPR/Cas9 generation of t(7;12)(q36;p13) chromosomal translocation
We recreated the t(7;12) translocation in K562 cells by CRISPR/Cas9 to understand its effects on haematopoietic cells, which is of relevance to understand how this cytogenetic abnormalities causes and promotes acute leukaemia in infants. Wild-type K562 were edited by electroporation of ribonucleopro...
ORGANISM(S): Homo sapiens 
2022-09-06 | E-MTAB-11851 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of MNX1 overexpression in hemogenic gastruloids
Analysis of MNX1 over expression in a 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production.
ORGANISM(S): Mus musculus 
2022-10-10 | E-MTAB-12149 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of RUNX1-RUNX1T1(9a) transformed mouse bone marrow cells
Single-cell RNA sequencing analysis of RUNX1-RUNX1T1(9a) transformed c-kit positive cells with (Kat2a WT) and without Kat2a (Kat2a NULL). Lineage negative bone marrow cells were collected from Kat2a fl/fl Mx1-Cre-/- and Kat2a fl/fl Mx1-Cre +/- animals after pIpC treatment and transduced with RUNX1-...
ORGANISM(S): Mus musculus 
2022-08-24 | E-MTAB-10853 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Kit+CD24+ fractions in K562-t(7;12) compared to K562-control
K562 cells with a CRISPR-engineered t(7;12)(q36;p13) translocation (K562-t(7;12)) and control line transiently transfected with Cas9 only (K562-ctrl) were FACS sorted on positivity to surface markers Kit and CD24.
ORGANISM(S): Homo sapiens 
2025-09-12 | E-MTAB-15530 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic stem cells (mES) and hemogenic gastruloids with MNX1 overexpression
Bulk RNA sequencing of 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production with overexpression of MNX1 by lentiviral vector transduction
ORGANISM(S): Mus musculus 
2022-10-10 | E-MTAB-12173 | biostudies-arrayexpress
TranscriptomicsRNA-seq of engineered K562 cell line with t(7;12)(q36;p13) treated with SNX-2112 and OSI930
K562-t(7;12) cells (K562 background with CRISPR/Cas9 engineered t(7;12) translocation) were treated with SNX-2112 (210 nM), OSI930 (9.19 µM), or DMSO (control) (0.1%) for 24 hours.
ORGANISM(S): Homo sapiens 
2025-09-12 | E-MTAB-15526 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MOLM-13 acute myeloid leukemia cell line treated with FIDAS-5
MOLM-13 acute myeloid leukemia cells were treated with 3 µM FIDAS-5 methionine S-adenosyltransferase 2A (MAT2A) inhibitor or 0.1% DMSO as control for 48 hours
ORGANISM(S): Homo sapiens 
2023-04-22 | E-MTAB-12847 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MOLM-13 acute myeloid leukemia cell line treated with single and combination 5-Azacytidine and CB-5083
MOLM-13 acute myeloid leukemia cells were treated with 7 µM 5-Azacytidine (Cayman Chemical 11164), or 450 nM CB-5083 (Cayman Chemical 19311), or in combination, or 0.1% DMSO as control. Treatments were conducted for 48 hours.
ORGANISM(S): Homo sapiens 
2023-04-22 | E-MTAB-12848 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of gastruloid hemogenic development
Time-course analysis of cell type specification in a 3-dimensional gastruloid differentiation system initiated from mouse embryonic stem (ES) cells and biased towards hemato-endothelial cell production.
ORGANISM(S): Mus musculus 
2022-10-09 | E-MTAB-12148 | biostudies-arrayexpress
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