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ProteomicsRiluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) rev...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034961 | Pride
Protein complex assembly Rna polymerase iii Mass spectrometry Paqosome Riluzole Polr3-related leukodystrophy 4h leukodystrophy Drug repurposing 
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