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ProteomicsRiluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) rev...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034961 | Pride
Protein complex assembly Rna polymerase iii Mass spectrometry Paqosome Riluzole Polr3-related leukodystrophy 4h leukodystrophy Drug repurposing 
ModelsWang2008 - Mimicking the inhibitory effect of riluzole on membrane conductance in skeletal fibres
Wang2008 - Mimicking the inhibitory effect of riluzole on membrane conductance in skeletal fibres This model is described in the article: Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells. ...
2024-09-02 | BIOMD0000000693 | BioModels
GenomicsRiluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling
Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling
PRJNA1055952 | ENA
GenomicsRiluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
Riluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
PRJNA734572 | ENA
GenomicsPharmacological rescue of motor neuron health by riluzole in patient-derived motor neurons
Pharmacological rescue of motor neuron health by riluzole in patient-derived motor neurons
PRJNA1336190 | ENA
TranscriptomicsRiluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling
Colorectal cancer is the second leading cause of cancer mortality in the US. Although immune checkpoint blockade therapies such as anti-PD-1/PD-L1 have had successes in some patients, the response rate is still low. We have found that riluzole, a well-tolerated FDA-approved oral medicine for treatin...
ORGANISM(S): Mus musculus 
2024-09-27 | GSE251940 | GEO
Methylation profilingRiluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
Dyskinesias are characterized by abnormal repetitive involuntary movements due to dysfunctional neuronal activity. Although levodopa-induced dyskinesia, characterized by tic-like abnormal involuntary movements, has no clinical treatment for Parkinson’s disease patients, animal studies indicate that ...
ORGANISM(S): Rattus norvegicus 
2021-06-03 | GSE176004 | GEO
TranscriptomicsPharmacological rescue of motor neuron health by riluzole in patient-derived motor neurons
Heterogeneous and predominantly sporadic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) remain highly challenging to model. Patient-derived induced pluripotent stem cell (iPSC) technologies offer great promise for these diseases, however large-scale studies demonstrating acce...
ORGANISM(S): Homo sapiens 
2025-11-02 | GSE309506 | GEO
ClinicalEffectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.
It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients ≥18 years old that have developed stage II/III colorectal cancer and are eligible for Simplified FOLFOX4 (6-12 cycles) adjuvant chemotherapy. The p...
2288100 | ecrin-mdr-crc
UnknownDipeptide Prodrugs of the Glutamate Modulator Riluzole.
Not available
S-EPMC6047042 | biostudies-literature
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