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ProteomicsiTRAQ MS of mouse LbetaT2 cells transfected with Galphas siRNA vs. scrambled siRNA
Twenty million LbetaT2 cells were transfected with either control or Galphas siRNA, then were seeded in 100-mm cell culture plates in DMEM + 10% FBS. Two days later, cells were washed twice with pre-warmed PBS. Conditioned media was harvested another 24 h later, and centrifuged at 20,000 g for 10 mi...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD000063 | Pride
Pituitary gonadotrope-derived lbetat2 cells Ab sciex tof/tof 5800 Mouse 
TranscriptomicsOptimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes.
Identifying the early gene program induced by GnRH would help understand how GnRH-activated signaling pathways modulate gonadotrope secretory response. We previously analyzed GnRH-induced early genes in LbT2 cells, however these lack GnRH self-potentiation, a physiological attribute of gonadotropes....
ORGANISM(S): Rattus norvegicus 
2011-08-16 | E-GEOD-31399 | biostudies-arrayexpress
TranscriptomicsExpression data from colorectal cancer patients
The study consist of patients who presented at Memorial Sloan-Kettering Cancer Center with a colonic neoplasm between 1992 and 2004. Biological specimens used in this study include primary colon adenocarcinomas, adenomas, metastasis and corresponding normal mucosae. 390 expression arrays
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-41258 | biostudies-arrayexpress
TranscriptomicsA growth differentiation factor 9 (GDF9) motif regulates follicle-stimulating hormone b-subunit (FSHb) gene expression: involvement of activin receptor-like kinase receptors 4/5 (ALK4/5) in the induction of FSHb by GDF9
Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses from the hypothalamus. GnRH regulates follicle-stimulating hormone b-subunit (FSHb) gene expression in pituitary gonadotropes in a frequency-sensitive manner that is central to reproductive physiology. The mechanisms underlying the p...
ORGANISM(S): Mus musculus 
2013-11-22 | E-GEOD-52631 | biostudies-arrayexpress
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