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ProteomicsRole of Late Endosomal Autophagy-Dependent Secretion in Regulating ER and Mitochondrial Stress and Stress Communication
Late endosomal secretion is an unconventional mechanism that relies on VAMP7 and is upregulated in autophagy-null cells. Transcriptomic analysis of VAMP7 knockout (KO) cells revealed significant changes in the expression of genes related to the mitochondria and endoplasmic reticulum (ER) stress. We ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-26 | PXD057152 | Pride
Mitochondrail stress Autophagy Vamp7 
TranscriptomicsEffect of fipronil on the thyroid gland transcriptome in the rat
Fipronil is a widely-used broad-spectrum phenylpyrazole insecticide. It has been shown that fipronil increases the hepatic metabolism of thyroid hormone in the rat, which may induce compensatory mechanisms at the level of the thyroid gland itself. Here, we studied the effect of fipronil on the trans...
ORGANISM(S): Rattus norvegicus 
2016-09-07 | E-GEOD-75275 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptome of rats treated with vehicle or fipronil (3 mg/kg/d per os for 14 days)
Fipronil (CAS #: 120068-37-3), a widely used insecticide, has been described as a thyroid disruptor in rat inducing a marked increase in thyroxine (T4) clearance resulting in a decrease in T4 plasma concentration. These effects seem to require the bioactivation of fipronil via its biotransformation ...
ORGANISM(S): Rattus norvegicus 
2013-08-22 | E-GEOD-39378 | biostudies-arrayexpress
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