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The PINK1/Parkin pathway is responsible for targeting damaged mitochondria for degradation via mitophagy. Because genetic evidence links impaired mitophagy to Parkinson’s disease, pharmacologic enhancement of mitophagy represents a promising disease-modifying strategy. Here, we characterize two phar...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058150 | Pride
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy
Damaged mitochondria can be cleared from the cell by mitophagy, using a pathway formed by the recessive Parkinson’s disease genes PINK1 and Parkin. Whether the pathway senses diverse forms of mitochondrial damage by a common mechanism, however, remains uncertain. Here, using a novel Parkin reporter ...
ORGANISM(S): Homo sapiens 
2025-08-06 | GSE298056 | GEO
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