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UnknownDefective autophagy is a key feature of cerebral cavernous malformations.
Not available
S-EPMC4644374 | biostudies-literature
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
UnknownAn intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress.
Not available
S-EPMC11473679 | biostudies-literature
TranscriptomicsConstitutively active Stat3 in mouse embryonic fibroblasts (MEFs)
Signal Transducer and Activator of Transcription 3 (STAT3) is considered as an oncogene being constitutively activated in a wide variety of primary human tumours, which often become addicted to its activity. Using primary fibroblasts derived from a knock-in mouse expressing only the constitutively a...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-21507 | biostudies-arrayexpress
UnknownDysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
Not available
S-EPMC11293339 | biostudies-literature
UnknownCombined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors.
Not available
S-EPMC12848005 | biostudies-literature
TranscriptomicsSystemic elevation of PTEN induces a tumor suppressive metabolic state
Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with variably elevated PTEN expression levels, ta...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-35670 | biostudies-arrayexpress
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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