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ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [CLK_ChIP]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47144 | biostudies-arrayexpress
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [MNase-Seq]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47142 | biostudies-arrayexpress
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [H2AZ-ChIP]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47143 | biostudies-arrayexpress
ProteomicsASCL1: a pioneer factor that induces subtype switching and characterizes adrenergic neuroblastoma
Neuroblastoma is an embryonic malignancy originating from early nerve cells. Neuroblastoma retains plasticity, interconverting between the mesenchymal (MES) and adrenergic (ADRN) states, which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-12-08 | PXD037670 | Pride
Ascl1 Subtype switching Neuroblastoma Pioneer factor Core regulatory circuit 
GenomicsLFY is pioneer transcription factor [RNA-seq]
LFY is pioneer transcription factor [RNA-seq]
PRJNA594413 | ENA
GenomicsLFY is pioneer transcription factor [ChIP-seq]
LFY is pioneer transcription factor [ChIP-seq]
PRJNA594412 | ENA
GenomicsLFY is pioneer transcription factor [MNase-seq]
LFY is pioneer transcription factor [MNase-seq]
PRJNA594411 | ENA
GenomicsPioneer factor-nucleosome binding events during differentiation are motif-encoded
Pioneer factor-nucleosome binding events during differentiation are motif-encoded
PRJNA527856 | ENA
GenomicsLFY is pioneer transcription factor
LFY is pioneer transcription factor
PRJNA594407 | ENA
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