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ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [CLK_ChIP]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47144 | biostudies-arrayexpress
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [MNase-Seq]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47142 | biostudies-arrayexpress
GenomicsCLK:BMAL1 is a pioneer-like transcription factor [H2AZ-ChIP]
The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its tar...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-47143 | biostudies-arrayexpress
GenomicsLFY is pioneer transcription factor [RNA-seq]
LFY is pioneer transcription factor [RNA-seq]
PRJNA594413 | ENA
GenomicsLFY is pioneer transcription factor [ChIP-seq]
LFY is pioneer transcription factor [ChIP-seq]
PRJNA594412 | ENA
GenomicsLFY is pioneer transcription factor [MNase-seq]
LFY is pioneer transcription factor [MNase-seq]
PRJNA594411 | ENA
GenomicsLFY is pioneer transcription factor
LFY is pioneer transcription factor
PRJNA594407 | ENA
TranscriptomicsNeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
Cell fate specification relies on the action of critical transcription factors that become available at distinct stages of embryonic development. One such factor is NeuroD1, which is essential for eliciting the neuronal development program and possesses the ability to reprogram other cell types into...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-65072 | biostudies-arrayexpress
ProteomicsASCL1: a pioneer factor that induces subtype switching and characterizes adrenergic neuroblastoma
Neuroblastoma is an embryonic malignancy originating from early nerve cells. Neuroblastoma retains plasticity, interconverting between the mesenchymal (MES) and adrenergic (ADRN) states, which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-12-08 | PXD037670 | Pride
Ascl1 Subtype switching Neuroblastoma Pioneer factor Core regulatory circuit 
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