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ProteomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-20 | PXD011415 | Pride
Pirna transposons piwi nuclear export 
TranscriptomicsUAP56 couples piRNA clusters to the perinuclear transposon silencing machinery [tiling array]
The transposon silencing piRNAs are produced from precursors that are encoded by heterochromatic clusters and processed in the perinuclear nuage. We show that the Drosophila nuclear DEAD box protein UAP56, previously implicated in mRNA splicing and nuclear export, co-localizes with the cluster-assoc...
ORGANISM(S): Drosophila melanogaster 
2012-11-28 | E-GEOD-35636 | biostudies-arrayexpress
TranscriptomicsUAP56 couples piRNA clusters to the perinuclear transposon silencing machinery [RNA-Seq and RIP-Seq]
The transposon silencing piRNAs are produced from precursors that are encoded by heterochromatic clusters and processed in the perinuclear nuage. We show that the Drosophila nuclear DEAD box protein UAP56, previously implicated in mRNA splicing and nuclear export, co-localizes with the cluster-assoc...
ORGANISM(S): Drosophila melanogaster 
2012-11-28 | E-GEOD-35637 | biostudies-arrayexpress
ProteomicsSpecialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
The piRNA pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilisation. In Drosophila ovaries, most piRNAs originate from dual-strand clusters, which generate piRNAs from both genomic strands. Dual-strand clusters use...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-07-29 | PXD014472 | Pride
Pirna rna export piwi drosophila transposons 
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
TranscriptomicsThe exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript
The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex which binds RNAs during splicing and remains associated with them following export to the cytoplasm. While the role of this complex in mRNA localization, translation and degradation has been well characterized, its mecha...
ORGANISM(S): Drosophila melanogaster 
2014-08-14 | E-GEOD-59327 | biostudies-arrayexpress
TranscriptomicsThe genetic framework of the Drosophila piRNA pathway
The animal piRNA pathway is a small RNA silencing system that acts in gonads and protects the genome against the deleterious influence of transposons. A major bottleneck in the field is the lack of comprehensive knowledge of the factors and molecular processes that constitute this pathway. We conduc...
ORGANISM(S): Drosophila melanogaster 
2013-05-10 | E-GEOD-45894 | biostudies-arrayexpress
GenomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
piRNA-guided co-transcriptional silencing coopts nuclear export factors
PRJNA498057 | ENA
ProteomicsRequirement of Nuclear Pore Complex subunits for transposon silencing in Drosophila
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. In Drosophila ovaries, piRNAs are produced from discrete genomic loci, called piRNA clusters, which are composed of inactive transposon copies and fragments and thus constitute a genetical...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-16 | PXD019671 | Pride
Pirna piwi npc nuclear export 
ProteomicsRequirement of Nuclear Pore Complex Subunits for transposon silencing in Drosophila
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. In Drosophila ovaries, piRNAs are produced from discrete genomic loci, called piRNA clusters, which are composed of inactive transposon copies and fragments and thus constitute a genetical...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-15 | PXD019670 | Pride
Pirna piwi npc nuclear export 
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