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TranscriptomicsExpression data of hepatic iNKT cells from pLck-hCD1d transgenic mice
CD1d expression by thymocytes is required to select iNKT cells. When CD1d is expressed only on thymocytes (pLck-CD1d tg mice), iNKT cells are hyperresponsive to antigen stimulation suggesting that, in physiological conditions, these cells undergo functional education mediated by additional CD1d-expr...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42835 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of OX40-triggered mouse Treg
Regulatory T (Treg) maintain the tumor microenvironment in an immunosuppressive state preventing effective anti-tumor immune response. A possible strategy to overcome Treg cell suppression focuses on OX40, a costimulatory molecule expressed constitutively by Treg cells while induced in activated eff...
ORGANISM(S): Mus musculus 
2011-09-25 | E-GEOD-32373 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of 2 different prostate tumor cell lines isolated from 30 wks old TRAMP mice compared to normal prostate
Analysis of gene expression of 2 novel prostate tumor cell lines isolated from TRAMP mice and compared to normal prostate. T1525 cell line is a well differentiated adenocarcinoma with epithelial features, whereas T23 cell line displays the molecular signature of epithelial-to-mesenchymal transition....
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-29957 | biostudies-arrayexpress
TranscriptomicsMast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers.
This SuperSeries is composed of the following subset Series: GSE29956: Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated. GSE29957: Gene expression analysis of 2 different prostate tumor cell lines isolated fr...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-29958 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.
Analysis of gene expression of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.The hypothesis tested in the present study was that mast cells inhibition or absence impacted prostate tumor development and histotype. Results demonstrate ...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-29956 | biostudies-arrayexpress
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