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TranscriptomicsFasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival
Short-term fasting protects mice from lethal doses of chemotherapy through undetermined mechanisms. Herein, we demonstrate that fasting preserves small intestinal (SI) architecture by maintaining SI stem cell viability and SI barrier function following exposure to high-dose etoposide. Nearly all SI ...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-72122 | biostudies-arrayexpress
UnknownSuppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.
Not available
S-EPMC3262072 | biostudies-literature
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Affymetrix]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46686 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis
Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...
ORGANISM(S): Homo sapiens 
2006-02-07 | E-MEXP-555 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Seq]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46688 | biostudies-arrayexpress
GenomicsEstrogen Receptor Positive Breast Cancer: Aromatase Inhibitor Response Study

Highly variable outcomes are observed in patients with estrogen receptor positive (ER+) breast cancer who undergo preoperative estrogen deprivation therapy with aromatase inhibitors (AI). In this study, 46 tumor and normal genomes and 31 exomes of participants selected from two clinical trials of...

phs000472.v1.p1 | EGA
TranscriptomicsDiscovery of PDE7B as a novel effector of GBM growth by computational deconvolution of an in vitro physical coculture system
Cell-to-cell interactions between tumor cells and their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported stem cell niche. We hypothesized that genes that media...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-51253 | biostudies-arrayexpress
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