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TranscriptomicsHuman pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease
Trophoblast is the primary epithelial cell type in the placenta, a transient organ required for proper fetal growth and development. We have identified a CDX2+/p63+ cytotrophoblast (CTB) subpopulation in the early post-implantation human placenta, which is significantly reduced later in gestation. C...
ORGANISM(S): Homo sapiens 
2016-06-16 | E-GEOD-76090 | biostudies-arrayexpress
TranscriptomicsGene expression profiling reveals a novel regulatory role for Sox21 in mouse trophoblast stem cell differentiation.
In this study we introduced Sox21 as a new regulator of trophoblast stem cell (TSC) differentiation. The transcriptome of different cell types were analyzed and compared to identify a TSC gene signature. In order to identify novel TSC specific genes, we performed genome-wide expression profiling of ...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-67037 | biostudies-arrayexpress
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
TranscriptomicsBMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
We show that FCM-BMP4-treated hESC differentiate into bona fide CTB by direct comparison to primary human placental tissues and isolated CTB through gene expresson profiling. We have compared gene expression profiling of FCM-BMP4-treated hESC to a panel of fetal tissues and first trimester tissues. ...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-49354 | biostudies-arrayexpress
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