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ProteomicsMass Spectrometry Methods and Mathematical PK/PD Model for Decision Tree-Guided Covalent Drug Development
Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect [i.e., uncoupling of pharmacokinetics (PK) and pharmacodynamics (PD...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD046903 | Pride
Covalent drug discovery Als Intact protein mass spectrometry Pk/pd 
GenomicsTransplanted human organoids empower PK/PD assessment of drug candidate for the clinic
Transplanted human organoids empower PK/PD assessment of drug candidate for the clinic
PRJNA693268 | ENA
UnknownPopulation PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197.
Not available
S-EPMC4759708 | biostudies-literature
UnknownAccelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug.
Not available
S-EPMC7998456 | biostudies-literature
TranscriptomicsTransplanted human organoids empower PK/PD assessment of drug candidate for the clinic
Pharmacokinetic/pharmacodynamic (PK/PD) studies are an essential component of pre-clinical drug discovery. Current best approaches for PK/PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translatability to the human co...
ORGANISM(S): Homo sapiens Rattus norvegicus 
2022-06-14 | GSE165104 | GEO
ModelsDayneka1993 - Theophylline-like 2-compartment PK with indirect PD response
Two-compartment PK model with Michaelis-Menten clearance and indirect PD response (Model IV). Theophylline-like diagnostic benchmark; not fitted to clinical data.
2026-06-27 | MODEL2605260001 | BioModels
UnknownCombined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia.
Not available
S-EPMC9138011 | biostudies-literature
UnknownPK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK-PD modeling from nonclinical to clinical development.
Not available
S-EPMC10087074 | biostudies-literature
UnknownIn vivo Pharmacokinetic and Pharmacodynamic (PK/PD) Modeling and Establishment of the PK/PD Cutoff of Florfenicol Against Pasteurella multocida in Ducks.
Not available
S-EPMC7829356 | biostudies-literature
UnknownModel-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Not available
S-EPMC8048880 | biostudies-literature
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