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ProteomicsPKA plays a conserved role in regulating gene expression and metabolic adaptation
PKA regulates metabolism adaptation by phosphorylating Rpd3/HDAC1
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-12 | PXD058634 | Pride
Pka hdac1 rpd3 
TranscriptomicsTranscription profiling of wild type and rpd3- yeast cells in response to osmotic stress
Comparison of wild type and rpd3- S. cerevisiae cells in response to osmotic stress. Wild type (MATalpha ura3 leu2 his3) and rpd3- (MATalpha ura3 leu2 his3 rpd3::KANMX) were grown to OD660=1 in YPD media and then subjected or not to a brief osmotic stress (5 or 20 min / 0.4 M NaCl). Cells were colle...
ORGANISM(S): Saccharomyces cerevisiae 
2004-01-22 | E-MEXP-48 | biostudies-arrayexpress
UnknownPKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1.
Not available
S-EPMC12041213 | biostudies-literature
GenomicsCUT&Tag analysis of HDAC1 binding profile with or without PKA inhibitor H89 treatment
CUT&Tag analysis of HDAC1 binding profile with or without PKA inhibitor H89 treatment
PRJNA1200812 | ENA
GenomicsCUT&Tag analysis of HDAC1 binding profile with or without PKA inhibitor H89 treatment
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) complex has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance its ability to acetylate nucleosomes and facilitate metabol...
ORGANISM(S): Homo sapiens 
2025-03-12 | GSE285017 | GEO
TranscriptomicsA genome-wide genetic interaction screen reveals metabolic roles of human histone deacetylase 1
Dynamic acetylation of metabolic proteins has emerged as a ubiquitous post-translational modification of human metabolic proteins. However, the corresponding modifying enzymes and the functions of the modification await exploration. Using a genome-wide synthetic lethality screen, we constructed a ge...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-29662 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of wild typeHDAC1 and HDAC1_S434A Transcriptomes with or without PKA inhibitor H89 treatment
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) complex has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance its ability to acetylate nucleosomes and facilitate metabol...
ORGANISM(S): Homo sapiens 
2025-03-12 | GSE284216 | GEO
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of wild typeHDAC1 and HDAC1_S434A Transcriptomes with or without PKA inhibitor H89 treatment
Next Generation Sequencing Facilitates Quantitative Analysis of wild typeHDAC1 and HDAC1_S434A Transcriptomes with or without PKA inhibitor H89 treatment
PRJNA1198008 | ENA
TranscriptomicsRNA-Seq profiling of C2C12 cells with exogenous expression of Mef2Da1 and Mef2Da2
Although splicing occurs in most multi-exon genes, the generation of distinct isoforms through the alternate use of mutually exclusive exons is less prevalent. As exon-switching events have the potential to give rise to isoforms with different cellular functions, we have explored the role of the mus...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-46363 | biostudies-arrayexpress
UnknownNegative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
Not available
S-EPMC343812 | biostudies-literature
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