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MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
GenomicsNeuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
PRJNA1256261 | ENA
UnknownDopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway.
Not available
S-EPMC8691485 | biostudies-literature
ProteomicsCaspase inhibition restores dopaminergic identity through the PKA–CREB–BDNF axis in Parkinson’s disease neurons
The progressive loss of dopaminergic identity in midbrain neurons is a hallmark of Parkinson’s disease (PD), contributing to synaptic dysfunction and neurodegeneration. However, the molecular mechanisms linking disease-specific stress to dopaminergic transcriptional failure remain poorly understood....
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD066765 | Pride
Synaptic function Parkinson’s disease Midbrain dopaminergic neurons Neurodegeneration Pka-creb pathway Apoptosis Qvd-oph 
GenomicsOSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway
OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway
PRJNA1496779 | ENA
UnknownMolecular Mechanism of Tetramethylpyrazine Ameliorating Neuroexcitotoxicity through Activating the PKA/CREB Signaling Pathway.
Not available
S-EPMC8794663 | biostudies-literature
TranscriptomicsTranscription profiling of mouse S49 lymphoma cell deathless (D-) cell variant
The second messenger cAMP acts via protein kinase A (PKA) to induce apoptosis by mechanisms that are poorly understood. Here, we assessed a role for mitochondria and analyzed gene expression in cAMP/PKA-promoted apoptosis by comparing wild-type (WT) S49 lymphoma cells and the S49 variant, D- (cAMP-d...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9727 | biostudies-arrayexpress
UnknownCannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.
Not available
S-EPMC9577756 | biostudies-literature
UnknownPrefrontal TRPM8 Receptor Modulates Epileptic Seizures via PKA/CREB Signaling Pathway in Mice.
Not available
S-EPMC12755055 | biostudies-literature
UnknownRhynchosia volubilis Promotes Cell Survival via cAMP-PKA/ERK-CREB Pathway.
Not available
S-EPMC8778899 | biostudies-literature
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