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ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
TranscriptomicsProbe to gene expressions in HIV infected CD4 T cells in the presence of CDK, caspase inhibitors and Nef
HIV-1 infection selectively alters gene expressions of CD4 T cells. To understand the effects of HIV to the expressions of CDK and caspase pathway genes in the presence and absence of Nef, we infected CD8-depleted PBMC from healthy donors with HIV-1 BAL in the presence of BB-94, PD-0332991, QVD-OPH ...
ORGANISM(S): Homo sapiens 
2023-11-23 | GSE218175 | GEO
UnknownNecroptosis induced by RIPK3 requires MLKL but not Drp1.
Not available
S-EPMC3944236 | biostudies-literature
TranscriptomicsGene expression in helped versus helpless CD8 T cells
CD4+ ‘helper’ T cells (TH) are pivotal for the generation and maintenance of CD8+ T cell responses. ‘Helped’ CD8+ T cells receive signals during priming that prevent the induction of the pro-apoptotic molecule TRAIL during reactivation, thereby enabling robust secondary expansion. Conversely, ‘helpl...
ORGANISM(S): Mus musculus 
2011-11-26 | E-GEOD-33862 | biostudies-arrayexpress
UnknownA novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX.
Not available
S-EPMC11488301 | biostudies-literature
UnknownTheiler's murine encephalomyelitis virus leader protein is the only nonstructural protein tested that induces apoptosis when transfected into mammalian cells.
Not available
S-EPMC2698581 | biostudies-literature
UnknownAdenosine enhances cisplatin sensitivity in human ovarian cancer cells.
Not available
S-EPMC6298929 | biostudies-literature
UnknownPI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells.
Not available
S-EPMC4854383 | biostudies-literature
GenomicsProbe to gene expressions in HIV infected CD4 T cells in the presence of CDK, caspase inhibitors and Nef
Probe to gene expressions in HIV infected CD4 T cells in the presence of CDK, caspase inhibitors and Nef
PRJNA902679 | ENA
ProteomicsThe bacterial porin OmpA is an inhibitor of Bak-activation at mitochondria and blocks apoptosis of human cells infected with Chlamydia trachomatis
Many infectious agents have the need to inhibit host apoptosis, and various strategies are known. Chlamydia trachomatis is an obligate intracellular bacterium replicating in a vacuole in the human cytosol. Chlamydia-infected human cells are strongly protected against apoptosis. We here mapped this a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD011848 | Pride
Ompa Mitochondria Chlamydia trachomatis Apoptosis Bcl-2 
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